@article { author = {Gnoni, Martin and McCann, Timothy and Riva-Moscoso, Adrian and Príncipe-Meneses, Fortunato and Chambergo-Michilot, Diego}, title = {Acute pulmonary histoplasmosis related to occupational roofing: A case report of two brothers}, journal = {Current Medical Mycology}, volume = {7}, number = {4}, pages = {34-37}, year = {2021}, publisher = {Mazandaran University of Medical Sciences}, issn = {2423-3439}, eissn = {2423-3420}, doi = {10.18502/cmm.7.4.8409}, abstract = {Background and Purpose: Histoplasma capsulatum is the cause of a prevalent fungal disease in certain regions in the United States of America, like Ohio and the Mississippi River. Its clinical manifestations range from asymptomatic to life-threatening diseases,according to the immune system. A definitive diagnosis is made by biopsy.Case report: Two middle-aged brothers presented with a nine-day history of severe progressive dyspnea. Both were living in Cincinnati, Ohio, and encountered bird droppings 7 days prior to symptoms while working on a roofing project. It should be mentioned that they were not wearing masks. After extensive testing, they were diagnosed with acute pulmonary histoplasmosis. Both were successfully treated with azole-derivative fungal therapy.Conclusion: This is the first case of histoplasmosis acquired through occupational exposure related to roofing and is unique given the two patients were siblings }, keywords = {Fungal,Histoplasmosis,Ohio,Spores,United States}, url = {https://cmm.mazums.ac.ir/article_139758.html}, eprint = {https://cmm.mazums.ac.ir/article_139758_01be00210bd77ba588675d0d5f1832a6.pdf} }