@article { author = {Abastabar, Mahdi and Akbari, Abolfazl and Akhtari, Javad and Hedayati, Mohammad Taghi and Shokohi, Tahereh and Mehrad-Majd, hasan and Ghalehnoei, Hosseein and Ghasemi, Sahar}, title = {In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines}, journal = {Current Medical Mycology}, volume = {3}, number = {1}, pages = {25-29}, year = {2017}, publisher = {Mazandaran University of Medical Sciences}, issn = {2423-3439}, eissn = {2423-3420}, doi = {10.29252/cmm.3.1.25}, abstract = {Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, we investigated its effects on HeLa,SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 µM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined. Results: The obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. Among all the cell lines, the highest growth inhibition rate was obtained at the 4 μM concentration of patulin.Conclusion: Our results suggested that patulin could significantly decrease tumor growth in human cervical and colorectal cancer models.  }, keywords = {cancer,HeLa cells,Mycotoxin,Patulin}, url = {https://cmm.mazums.ac.ir/article_90353.html}, eprint = {https://cmm.mazums.ac.ir/article_90353_1ab2cbbe2b6c3612b06da2d619cf53ce.pdf} }