%0 Journal Article %T Catastrophic Candida prosthetic valve endocarditis and COVID-19 comorbidity: A rare case %J Current Medical Mycology %I Mazandaran University of Medical Sciences %Z 2423-3439 %A davoodi, Lotfollah %A Faeli, Leila %A Mirzakhani, Rogheye %A Jalalian, Rozita %A Shokohi, Tahereh %A Kermani, Firoozeh %D 2021 %\ 06/01/2021 %V 7 %N 2 %P 43-47 %! Catastrophic Candida prosthetic valve endocarditis and COVID-19 comorbidity: A rare case %K Candida endocarditis %K case report %K comorbidity %K COVID-19 %K Prosthetic valve replacement %K SARS-CoV-2 %K TRANSESOPHAGEAL ECHOCARDIOGRAPHY %R 10.18502/cmm.7.2.7157 %X Background and Purpose: Coronavirus disease 2019 (COVID-19) and Candida prostatic valve endocarditis present various clinical manifestations which may overlap;hence, discrimination between them is extremely difficult.Case report: The case was a 66-year-old man with a past medical history of mitral and aortic valves replacement one year before COVID-19 co-infection. He was admitted with fever (for 7 days), shortness of breath, cough, seizure, lethargy,headache, and 85% oxygen saturation. Transesophageal echocardiography revealed multiple large-sized, highly mobile masses on both sides of the mechanical mitral valve highly suggestive of vegetation. Chest computed tomography scanning showed simulating scattered COVID-19 peripheral ground-glass opacities confirmed by reverse-transcription polymerase chain reaction. The set of blood cultures yieldedyeast colonies that were identified as Candida tropicalis. The patient died of septic shock shortly after receiving antifungal therapy.Conclusion: This case emphasized the importance of early diagnosis andimplementation of antifungal treatment, particularly in patients with prosthetic cardiacvalves, to reduce their unfavorable outcomes in COVID-19 patients  %U https://cmm.mazums.ac.ir/article_136635_3ac6e6b059e65fbc106a370b18099822.pdf