TY - JOUR ID - 90383 TI - Kinetics of antifungal activity of home-generated ozonated water on Candida albicans JO - Current Medical Mycology JA - CMM LA - en SN - 2423-3439 AU - Mirmortazavi, Amirtaher AU - Rajati Haghi, Hamidreza AU - Fata, Abdolmajid AU - Zarrinfar, Hossein AU - Bagheri, Hossein AU - Mehranfard, Amirhossein AD - Department of Prosthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran AD - Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Dental Materials Research Center, Department of Operative Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2018 PY - 2018 VL - 4 IS - 2 SP - 27 EP - 31 KW - Antifungal KW - Candida KW - Denture KW - Ozonated water KW - stomatitis DO - 10.18502/cmm.4.2.67 N2 - Background and Purpose: Candida-associated denture stomatitis is one of the most common forms of oral candidiasis among denture wearers. Regarding this, the aim of the present study was to evaluate the antifungal effects of home-generated ozonated water on the adhesion of the C. albicans attached to the surface of the denture base acrylic resins. Materials and Methods: For the purpose of the study, different concentrations of C. albicans were added to the tubes containing acrylic resin blocks, and then incubated for 2 h at 35°C. The samples were assigned into three groups, each of which contained 42 samples, including normal saline (NS) solution as the negative control, nystatin (N) solution as the positive control, and ozonated water as the test group. The samples were washed and placed in an ultrasonic bath. Subsequently, the saline solution was cultured on Sabouraud dextrose agar. The concentrations of Candida were evaluated during the contact times. Results: The test group (i.e., ozonated water) with 114 colony-forming units (CFU) showed a significant reduction of Candida colonies, compared to the NS group with 2,172 CFU. The 120- and 1-minute incubation with ozonated water showed the highest and lowest effects on the viability of Candida adhered to the acrylic resin, respectively. Conclusion: Based on the findings, home-generated ozonated water can be applied to remove the Candida attached to the surface of the denture plates. UR - https://cmm.mazums.ac.ir/article_90383.html L1 - https://cmm.mazums.ac.ir/article_90383_5a9d78b05c59d77197a7805505038026.pdf ER -