Volume 2, Issue 3 (September 2016)                   Curr Med Mycol 2016, 2(3): 37-41 | Back to browse issues page

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Mamishi S, Zomorodian K, Saadat F, Jalali S Z, Geramishoar M. Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient. Curr Med Mycol. 2016; 2 (3) :37-41
URL: http://cmm.mazums.ac.ir/article-1-108-en.html
Abstract:   (2524 Views)

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients.

Case Report: Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma.

Conclusion: Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.

Full-Text [PDF 692 kb]   (1001 Downloads)    
Type of Study: Case report | Subject: Medical Mycology
Received: 2016/09/18 | Accepted: 2016/11/7 | Published: 2017/01/11

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