Volume 4, Issue 2 (June 2018)                   Curr Med Mycol 2018, 4(2): 21-26 | Back to browse issues page


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Sadeghi-Nejad B, Moghimipour E, Yusef Naanaie S, Nezarat S. Antifungal and antibacterial activities of polyherbal toothpaste against oral pathogens, in vitro. Curr Med Mycol. 2018; 4 (2) :21-26
URL: http://cmm.mazums.ac.ir/article-1-196-en.html
Abstract:   (160 Views)
Background and Purpose: Herbal toothpastes are more secure and efficacious and less poisonous due to containing natural chemicals as compared with the synthetic toothpastes. The present study aimed to formulate a polyherbal toothpaste using accessible medicinal plants in Iran and evaluate its efficiency in the protection of oral hygiene and prevention of dental caries.
Materials and Methods: The developed toothpaste was made of the leaf extracts of Artemisia dracunculus, Satureja khuzestanica (Jamzad), and Myrtus communis (Linn), combined at four different dilutions, namely 1:4 (25%), 1:1 (50%), 3:4 (75%), and (100%), with sterile distilled water. The product was tested against five microorganisms, including Streptococcus mutans, Lactobaccilus caseie, S. sanguis, S. salivarius, and Candida albicans, using agar well diffusion method.
Results: After 24 h of incubation, the maximum mean diameters of inhibition zone against L. caseie and C. albicans were obtained as 17-30 and 10-25 mm, respectively. Furthermore, the minimum mean diameter of inhibition zone against S. salivarious was estimated as 15-20 mm.
Conclusion: The formulated toothpaste showed potent inhibitory activities against Gram-positive bacteria and C. albicans. Therefore, more studies are required to accurately investigate the efficacy of the formulated toothpaste.
Full-Text [PDF 427 kb]   (63 Downloads)    
Type of Study: Original Articles | Subject: Pharmacy
Received: 2018/04/23 | Accepted: 2018/08/6 | Published: 2018/10/7

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