Design and investigating the vaginal gel using Securigera securidaca L. for the treatment fungal vaginitis

Document Type: Original Articles


1 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran


Background and aim: Candida species are opportunistic fungi capable of causing acute and chronic infections in the gastrointestinal tract, vagina and oral mucosa, among which the most important species is Candida albicans. The Securigera securidaca L. is used as an antiseptic to treat some diseases in traditional Iranian medicine. The aim of this study was to evaluate the antimicrobial activity of S. securidaca extracts and vaginal gel against different species of Candida.

Materials and Methods: Antifungal effects of different extracts and vaginal gel of S. securidaca have been investigated against Candida species. Different concentrations of the collected S. securidaca extracts and vaginal gel were examined to test the antifungal activity against C. albicans, C. parapsilosis and C. krusei using well diffusion test.

Results: The Ethanol extract and vaginal gel with ethanol extract of S. securidaca showed the most anti-fungal activity against all three strains.

Conclusion: The S. securidaca extract had a significant inhibitory effect on the different species of Candida, but the highest inhibitory effect was found against C. albicans. More research is required to check this plant performance to treat the Candidiasis.