Volume 3, Issue 1 (March 2017)                   Curr Med Mycol 2017, 3(1): 25-29 | Back to browse issues page


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Abastabar M, Akbari A, Akhtari J, Hedayati M T, Shokohi T, Mehrad-Majd H, et al . In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines. Curr Med Mycol. 2017; 3 (1) :25-29
URL: http://cmm.mazums.ac.ir/article-1-151-en.html
Abstract:   (1185 Views)
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity.
Materials and Methods: To determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, we investigated its effects on HeLa,SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 µM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined.
Results: The obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. Among all the cell lines, the highest growth inhibition rate was obtained at the 4 μM concentration of patulin.Conclusion: Our results suggested that patulin could significantly decrease tumor growth in human cervical and colorectal cancer models.
 
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Type of Study: Original Articles | Subject: Medical Mycology
Received: 2017/09/4 | Accepted: 2017/11/11 | Published: 2017/12/13

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