Volume 1, Issue 4 (December 2015)                   Curr Med Mycol 2015, 1(4): 33-36 | Back to browse issues page

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Berenji F, Zabolinejad N, Badiei Z, Kakhi S, Andalib Aliabadi Z, Ganjbakhsh M. Oropharyngeal candidiasis in children with lymphohematopoietic malignancies in Mashhad, Iran. Curr Med Mycol. 2015; 1 (4) :33-36
URL: http://cmm.mazums.ac.ir/article-1-68-en.html
Abstract:   (2528 Views)

Background and Purpose: Over the past years, the role of fungi as a cause of nosocomial infections in hospitalized patients has been accentuated. Candida species constitute an important group of fungi causing diseases in immunocompromised patients. Oropharyngeal candidiasis continues to be a prevalent infection in immunodeficient patients. In this study, we aimed to determine the incidence of oropharyngeal candidiasis in children with lymphohematopoietic malignancies.
Materials and Methods: In total, 102 patients with lymphohematopoietic malignancies and 50 healthy controls were examined in terms of Candida infections via direct sampling of the oropharyngeal cavity. Fresh smears were prepared with 10% potassium hydroxide and Gram staining was carried out. Subsequently, the obtained specimens were cultured on Sabouraud dextrose agar for further analysis.
Results: The most common Candida species were Candida albicans (31%), other non-C. albicans species (14.7%), C. glabrata (6.8%), and C. krusei (0.98%) in the case group, while in the control group, other non-C. albicans species (10%) and C. albicans (8%) were the most common species.
Conclusion: In the present study, Candida species were the most common fungal pathogens in pediatric cancer patients; therefore, efforts should be made to prevent fungemia and fungal pneumonia. Also, non-C. albicans species must be considered as a new risk factor for pediatric cancer patients.

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Type of Study: Original Articles |
Received: 2015/11/29 | Accepted: 2016/02/27 | Published: 2016/03/1

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