Volume 2, Issue 2 (June 2016)                   Curr Med Mycol 2016, 2(2): 28-33 | Back to browse issues page

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Sadeghi Ardestani Z, Falahati M, Sayah Alborzi S, Ashrafi Khozani M, Rostam khani F, Bahador A. The effect of nanochitosans particles on Candida biofilm formation. Curr Med Mycol. 2016; 2 (2) :28-33
URL: http://cmm.mazums.ac.ir/article-1-91-en.html
Abstract:   (2838 Views)

Background and Purpose: In people wearing dentures, the growth of various Candida species under the prosthesis
leads to the formation of biofilm, which can play the role of a reservoir for Candida and other kinds of microbes. Since
nano-chitosan particles can cause lasting antimicrobial activity, a more recent approach that utilizes acrylic resins with
nano-chitosan particles is proposed. Therefore, we aimed to study the inhibitory effect of nano-chitosan particles on the
biofilm formation of Candida species in acrylic resins.
Materials and Methods: In this analytical in-vitro study, acrylic resins with nano-chitosan particles with concentrations of
0, 1%, 5%, and 10% were put adjacent to the suspension of Candida cells isolated from the individuals’ mouth and biofilm
formation on resins was measured and compared. Finally, the data were analyzed using Kruskal-Wallis and Chi-square tests.
Results:The observed differences between unmodified acrylic resin (control) and acrylic resin with nano-chitosan
particles in terms of biofilm formation were significant (P<0.05), but no significant difference was found in the formation
of biofilm species on resins.
Conclusion: Biofilm formation of Candida species depends on acrylic resin type, in a way that by adding nano-chitosan
particles to acrylic resins, biofilm formation of Candida species was significantly reduced. To decrease the organization
of biofilm and denture stomatitis, the use of acrylics with nano-chitosan particles in producing dentures is recommended.

Full-Text [PDF 519 kb]   (1105 Downloads)    
Type of Study: Original Articles | Subject: Medical Mycology
Received: 2016/07/2 | Accepted: 2016/09/19 | Published: 2016/10/4

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