Overview of Candida parapsilosis candidemia in pediatric patients with hematologic and solid organ malignancies

Document Type : Original Articles

Authors

1 Department of Pediatric Infection, Faculty of Medicine, Cukurova University, Adana, Turkey

2 Department of Microbiology, Faculty of Medicine, Cukurova University, Adana, Turkey

3 Department of Biostatistics, Faculty of Medicine, Cukurova University, Adana, Turkey

4 Department of Pediatric Hematology, Faculty of Medicine, Cukurova University, Adana, Turkey

5 Department of Pediatric Oncology, Faculty of Medicine, Cukurova University, Adana, Turkey

10.22034/cmm.2024.345299.1579

Abstract

Background and Purpose: Today, with the development of critical patient care and the increase in intravascular invasive methods, the survival rate of patients diagnosed with hematological and solid organ malignancies is increasing, and unfortunately, the incidence of Candida parapsilosis candidemia is also increasing due to multiple risk factors. In this study, we aimed to determine the clinical-demographic characteristics of C. parapsilosis candidemia and the antifungal susceptibility profile of C. parapsilosis in pediatric patients with hematological and solid organ malignancies.
Materials and Methods: The present study included pediatric patients with hematologic and solid organ malignancies presenting with signs and symptoms consistent with candidemia, in whom C. parapsilosis was isolated from blood and catheter cultures between January 2010 and September 2024.
Results: Thirty (65.2%) of the patients had hematologic and 16 (34.8%) had solid organ malignancies. In all patients, 23 (50%) had non-catheter-related candidemia and 23 (50%) had catheter-related candidemia. At least one of the risk factors examined was detected in these patients. Catheter-related candidemia was found to be more common in patients diagnosed with hematologic malignancy. The difference was found to be statistically significant (p= 0.030). Drug resistance rates of C. parapsilosis were 6.5% for amphotericin B, 6.5% for fluconazole, 2.2% for voriconazole and 2.2% for micafungin. No patient with caspofungin resistance was detected. The mean treatment duration of the patients was 21 days (min 3-max 103) and it was observed that amphotericin B and caspofungin were used most frequently in the treatment regimen. The mortality rate of patients with candidemia was 6.5%.
Conclusion: Our study showed that patients with hematologic malignancies exhibited a higher susceptibility to catheter-related C. parapsilosis candidemia compared to patients with solid organ tumors. Caspofungin resistance was not detected in our study, and we believe that each center should know its own antifungal drug sensitivity, determine the treatment regimen accordingly, and that catheters should be removed rapidly in patients with catheter-related C. parapsilosis candidemia in malignant patients.

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Current Medical Mycology
Volume 10, Continuous
2024
Pages 1-7

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History

  • Receive Date: 01 October 2024
  • Revise Date: 05 December 2024
  • Accept Date: 21 December 2024
  • Publish Date: 19 March 2025

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