Oropharyngeal candidiasis in children with lymphohematopoietic malignancies in Mashhad, Iran

Authors

1 Prof.of Parasitology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

2 Associate Prof.of Pathology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

3 3. Associate Prof.of Pediatric Hematology, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

4 4. M.D, School of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran

5 5. Msc of Parasitology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

6 6. Msc Student of Mycology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Background and Purpose: Over the past years, the role of fungi as a cause of nosocomial infections in hospitalized patients has been accentuated. Candida species constitute an important group of fungi causing diseases in immunocompromised patients. Oropharyngeal candidiasis continues to be a prevalent infection in immunodeficient patients. In this study, we aimed to determine the incidence of oropharyngeal candidiasis in children with lymphohematopoietic malignancies.
Materials and Methods: In total, 102 patients with lymphohematopoietic malignancies and 50 healthy controls were examined in terms of Candida infections via direct sampling of the oropharyngeal cavity. Fresh smears were prepared with 10% potassium hydroxide and Gram staining was carried out. Subsequently, the obtained specimens were cultured on Sabouraud dextrose agar for further analysis.
Results: The most common Candida species were Candida albicans (31%), other non-C. albicans species (14.7%), C. glabrata (6.8%), and C. krusei (0.98%) in the case group, while in the control group, other non-C. albicans species (10%) and C. albicans (8%) were the most common species.
Conclusion: In the present study, Candida species were the most common fungal pathogens in pediatric cancer patients; therefore, efforts should be made to prevent fungemia and fungal pneumonia. Also, non-C. albicans species must be considered as a new risk factor for pediatric cancer patients.

Keywords


Volume 1, Issue 4
December 2015
Pages 33-36
  • Receive Date: 09 July 2019
  • Revise Date: 10 October 2020
  • Accept Date: 09 July 2019
  • Publish Date: 01 December 2015