Saprochaete clavata (Geotrichum clavatum) Septicemia In A Patient With Multiple Myeloma; An Emerging Case From Southeastern Turkey

Document Type : Case report

Authors

1 University Faculty of Medicine Dept.of Medical Microbiology Diyarbakır/Turkey

2 University Faculty of Medicine Dept.of Medical Microbiology

3 Dept.of Medical Microbiology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey

4 Dept.of Internal Medicine, Faculty of Medicine, Dicle University, Diyarbakır, Turkey

Abstract

Background and Purpose: Invasive fungal infections(IFI) are life-threatening infections that can be seen in immunocompromised patients with malignancy, undergoing chemotherapy or transplantation. Although Candida and Aspergillus species are the most common IFI agents, infections due to rare fungal species are also encountered.
A bloodstream infection due to Saprochaete clavata (formerly Geotrichum clavatum) was reported in a woman with multiple myeloma in this case report.
Case: A 59- years- old woman suffered from fever, widespread rashes and diarrhea after an autologous bone marrow transplantation. Peripheral blood cultures were taken from the patient and sent to the microbiology laboratory. Cultures grew white to cream- colored cottony colonies; septate and branched hyphae and arthroconidia were seen under microscope by lactophenol blue staining. The fungi colonies were identified by Maldi Biotyper 3.1. as S. clavata (G.clavatum)with a reliable score. Antifungal drug susceptibility test was carried out by Concentration Gradient Strip Etest Method. Minimal inhibitory concentrations of Amphotericin B, fluconazole, voriconazole, posaconazol and anidulafungin were determined as 4 mg/dL, 3 mg/dL, 0.125 mg/dL, 0.125 mg/dL and > 32 mg/dL, respectively. The patient died 3 days after identification of the fungi, despite amphotericin B treatment.

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