Document Type : Short Communication
Authors
1
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2
Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3
Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, SE, 75007, Uppsala, Sweden
4
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
5
Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
6
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
10.22034/cmm.2024.345183.1499
Abstract
Background and Purpose: Dorema species are well-known antifungal medicinal plants. Dorema kopetdaghense (Apiaceae family) is a rarely investigated endemic plant to Iran. The present study was aimed at assessing the antifungal, antibacterial, antioxidant, and cytotoxic activities of different plant’s root extracts.
Materials and Methods: The methanolic crude extract (MeOH) and its sub-fractions including petroleum ether (PE), dichloromethane (DCM), ethyl acetate (EtOAc), and n-butanol (n-BuOH) were prepared.
Results: Results from the antifungal and antibacterial activities of fractions indicated remarkable antifungal effects against C. albicans with MIC and MBC values of 10 µg/mL; however, no cytotoxicity was observed in the case of selected cancer cells. Moreover, methanolic soluble fractions showed good antiradical effects evaluated via DPPH and BCB tests possessing IC50 20.11 and 41.32 µg/mL, though it was less effective than positive controls ascorbic acid (8.47 and 31.71 µg/mL) and BHT (IC50: 10.29 and 33.55 µg/mL), respectively.
Conclusion: Taken together, strong antifungal and antioxidant activities without notable cytotoxicity, suggest the potential safety of the plant to be used as a natural antifungal remedy as well as a preservative in the food industry.
Keywords: Apiaceae, antimicrobial, cytotoxicity, Candida albicans
Keywords
Main Subjects
)