Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran
Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran
MSc Student, Department of Plant Breeding and Biotechnology, Faculty of Agriculture, University of Zabol, Zabol, Iran
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
Background and Purpose: In traditional medicine, herbal products still remain the principal source of pharmaceutical
agents. The present study aimed to investigate the antifungal effects of Echinophora platyloba and Rosmarinus officinalis
extracts on C. albicans species.
Materials and Methods: The aqueous and ethanolic leaf extracts of E. platyloba and R. officinalis, collected from the
mountainous regions of Iran, were screened in terms of antimicrobial activity against C. albicans strains, using the agar
well diffusion method. The minimum inhibitory concentration was determined by the microtitration technique.
Results: Overall, the results showed that the leaf extracts of E. platyloba and R. officinalis had strong antimicrobial
activities. Also, based on the findings, R. officinalis leaf extracts exhibited higher antimicrobial activity. The ethanolic
leaf extracts of E. platyloba and R. officinalis showed good antimicrobial activity against C. albicans strains. However,
the aqueous extracts did not show any major activities against the tested C. albicans strains. On the other hand, the
ethanolic extracts exhibited major antimicrobial properties against C. albicans strains. The highest minimum inhibitory
concentration was reported in E. platyloba leaf extracts.
Conclusion: The present results indicated some advantages of E. platyloba and R. officinalis leaf extracts, which could be
applied for the treatment of microbial infections