Antifungal properties of carvone and linalool against Malassezia species: Preliminary Screening Study

Document Type : Short Communication

Authors

1 Department of Medical Parasitology and Mycology,Shiraz University of Medical Sciences

2 Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

4 Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

10.22034/cmm.2024.345248.1547

Abstract

Background and Purpose: By harnessing the power of nature, researchers can potentially discover new therapeutic options that are safe, effective, and sustainable for the management of diseases. Recently, natural products have been extensively studied for the treatment of diseases due to their diverse chemical composition and potential therapeutic properties. Therefore, this study aimed to investigate the antifungal activity of carvone and linalool against Malassezia species to find alternative treatments for pityriasis versicolor.
Materials and Methods: The in vitro antifungal activity of monoterpenes was assessed using a microdilution method, following the guidelines specified in the Clinical and Laboratory Standards Institute document M27-A3 with modifications, including the use of Christensen’s urea broth supplemented with various lipids to optimize the growth condition for Malassezia.
Results: The minimum inhibitory concentration ranges for linalool and carvone were found to be 0.3-5.4 and 0.3-24 mg/mL, respectively. Additionally, the growth of Malassezia species was inhibited at concentrations of 0.001-0.003 and 0.006-0.1 mg/mL for amphotericin B and ketoconazole, respectively.
Conclusion: Given the remarkable antifungal properties exhibited by linalool and carvone against Malassezia species, these terpene compounds have the potential to be utilized for the treatment of Malassezia infections, provided that additional research is conducted.

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Main Subjects

Current Medical Mycology
Volume 10, Continuous
2024
Pages 1-5

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History

  • Receive Date: 21 July 2024
  • Revise Date: 05 November 2024
  • Accept Date: 12 November 2024
  • Publish Date: 25 November 2024

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