Nano-graphene to prevent pulmonary fungal infection

Articles in Press

Document Type : Reviews

Authors

1 Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

2 Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

4 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

10.22034/cmm.2025.345356.1618

Abstract

Nano-graphene oxide is a promising candidate for therapeutic applications, particularly due to its notable antifungal and antibacterial properties stemming from this innovative nanocarrier's unique physicochemical characteristics. The antifungal efficacy of nano-graphene oxide is increasingly attracting attention, particularly in light of the rising resistance of pathogens to conventional drug therapies. Upon exposure to graphene oxide, fungal cells generate reactive oxygen species, a key indicator of cellular oxidative stress. This mechanism accounts for the apoptotic-like cell death observed in the presence of graphene oxide. This nano-drug delivery system holds the potential to achieve therapeutic efficacy at lower doses, minimize side effects, enable controlled drug release, prolong circulation time, reduce toxicity, and enhance the stability of the nano-formulation, particularly when administered as an inhaled dry powder. However, the factors influencing the antifungal activity of nano-graphene oxide and the underlying mechanisms remain poorly understood. This article reviews the anti-pathogenic properties of nano-graphene oxide, focusing on its antifungal mechanisms and its role in biofilm formation associated with pulmonary fungal infections.

Keywords

Main Subjects

Current Medical Mycology

Articles in Press, Accepted Manuscript
Available Online from 07 April 2025

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History

  • Receive Date: 18 January 2025
  • Revise Date: 17 March 2025
  • Accept Date: 07 April 2025
  • Publish Date: 07 April 2025

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