In vitro antifungal properties of Pistacia atlantica and olive extracts on different fungal species


1 Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Abadan School of Medical Sciences, Abadan, Iran and Cellular, Molecular Research Center of Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran

3 Agricultural and Natural Resources Research Center


Background and Purpose: Pistacia atlantica, which belongs to the Anacardiaceae family, grows in the Zagrossian region of Iran. The aim of this study was to evaluate the antifungal properties of Pistacia atlantica and olive leaf extracts against different fungal species.
Materials and Methods: In this study, we assessed the activities of olive leaf extracts and Pistacia atlantica leaf and fruit extracts against Candida species, including C. albicans, C. glabrata, C. tropicalis, and C. krusei. In addition, antifungal activities against three filamentous species, i.e., Aspergillus niger, Aspergillus flavus, and Aspergillus fumigates, were assessed, using the agar-well diffusion method.
Results: The minimal inhibitory concentrations (MICs) values of fruit and leaf extracts from Pistacia atlantica ranged 6.25-12.5 mg ml-1 and 6.25-25 mg ml-1 against the tested Candida and Aspergillus species, respectively. The olive leaf extracts showed no activity against Candida species or Aspergillus flavus, while they exhibited antifungal potency against Aspergillus niger and Aspergillus fumigatus (MIC: 12.5-25 mg/ml). The MICs of the mixture of selected extracts ranged from 6.25 to 25 mg/ml.
Conclusion: Based on the results, the ethanolic extracts of the selected plants exhibited antifungal potency against the tested fungi and could be used as natural antifungal agents.


Volume 1, Issue 4
December 2015
Pages 40-45
  • Receive Date: 09 July 2019
  • Revise Date: 10 October 2020
  • Accept Date: 09 July 2019
  • First Publish Date: 09 July 2019