First report of Vulvovaginitis due to Cryptococcus magnus in Iran


1 1Department of Medical Parasitology and Mycology, school of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medial Sciences, Tehran, Iran


Background and Purpose: Cryptococcus. magnus is a non-Cryptococcus neoformans
species isolated from certain plants, soil, air, and arctic glaciers.
Case report: This report describes a case of a 23-year-old Iranian female with pruritus
and vaginal irritation. Conventional tests and molecular analysis of the samples of
vaginal discharge were performed. The mentioned analyses revealed Cryptococcus
magnus as the causative agent of vaginal infection. The minimum inhibitory
concentration analysis revealed that this species is susceptible to itraconazole,
fluconazole, ketoconazole, and amphotericin B. The patient received 200 mg of oral
ketoconazole once daily for 10 days. The patient did not show any clinical signs of
vaginal infection after six months.
Conclusion: C. magnus was found to have the ability to cause vulvovaginitis. This is the
first report of successful detection and treatment of vulvovaginal infection with C.


Volume 4, Issue 1
March 2018
Pages 30-33
  • Receive Date: 09 July 2019
  • Revise Date: 09 October 2020
  • Accept Date: 09 July 2019
  • First Publish Date: 09 July 2019
  • Publish Date: 01 March 2018