Disseminated Cryptococcosis in an HIV patient with Hepatitis C as an associated risk factor

Articles in Press

Document Type : Case report

Authors

1 Department of Microbiology, Government Medical College and Hospital, Chandigarh

2 Department of General Medicine Government Medical College and Hospital Chandigarh India

3 Department of Microbiology, Government Medical College Hospital (GMCH), Chandigarh

10.22034/cmm.2025.345333.1600

Abstract

Introduction: In the context of HIV/AIDS, cryptococcosis emerges as one of the most common opportunistic infections, with a predilection for affecting individuals with compromised immune function.
Case Report: Hereby, we present a compelling case of disseminated cryptococcosis in a 29-year-old male with a complex medical history, marked by HIV infection, hepatitis C, and a longstanding history of intravenous (IV) drug abuse. The patient’s blood sample as well as the CSF sample grew Cryptococcus neoformans. An immunochromatographic test done on CSF and serum sample was also positive.
Conclusion:  Chronic HCV can disrupt the blood-brain barrier and cause neuroinflammation predisposing the CNS to hematogenous seeding during fungemia. The patient's multifaceted medical background underscores the challenges in managing comorbidities.

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Main Subjects

Current Medical Mycology

Articles in Press, Accepted Manuscript
Available Online from 07 February 2025

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History

  • Receive Date: 12 December 2024
  • Revise Date: 23 January 2025
  • Accept Date: 07 February 2025
  • Publish Date: 07 February 2025

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